| Award | Player | Team |
| Player of the Year | Carson Palmer | Cincinnati |
| Front Office Bowl MVP | Colt McCoy | Oakland |
| Coach of the Year | Mike Charles | New York (A) |
| Legend of the Game | Orlando Sheehan | Dallas |
| Offensive Player of the Year | Carson Palmer | Cincinnati |
| Defensive Player of the Year | Stephen Tulloch | Minnesota |
| Offensive Rookie of the Year | DeMarco Murray | Kansas City |
| Defensive Rookie of the Year | Nate Irving | New York (N) |
| All-League First Team Quarterback | Carson Palmer | Cincinnati |
| All-League First Team Running Back | LeGarrette Blount | Buffalo |
| All-League First Team Fullback | Dexter Lyon | Tampa Bay |
| All-League First Team Tight End | Jared Cook | Miami |
| All-League First Team Wide Receiver | Matt Jones | Carolina |
| All-League First Team Wide Receiver | Stevie Johnson | Minnesota |
| All-League First Team Center | Jason Brown | San Francisco |
| All-League First Team Offensive Guard | Ramon Foster | Kansas City |
| All-League First Team Offensive Guard | Oniel Cousins | Denver |
| All-League First Team Offensive Tackle | Allen Barbre | New York (A) |
| All-League First Team Offensive Tackle | Michael Roos | Buffalo |
| All-League First Team Punter | Dustin Colquitt | Houston |
| All-League First Team Kicker | Robbie Gould | San Diego |
| All-League First Team Defensive End | Stephen Tulloch | Minnesota |
| All-League First Team Defensive End | Athyba Rubin | Atlanta |
| All-League First Team Defensive Tackle | Kevin Williams | Denver |
| All-League First Team Defensive Tackle | Johnny Jolly | Pittsburgh |
| All-League First Team Inside Linebacker | A.J. Hawk | Kansas City |
| All-League First Team Outside Linebacker | Jason Babin | Tennessee |
| All-League First Team Outside Linebacker | Nic Harris | Carolina |
| All-League First Team Cornerback | Leon Hall | Cleveland |
| All-League First Team Cornerback | Asante Samuel | Washington |
| All-League First Team Safety | Tracy Porter | Jacksonville |
| All-League First Team Safety | Quintin Demps | Cincinnati |
| All-League Second Team Quarterback | Vince Young | Dallas |
| All-League Second Team Running Back | DeMarco Murray | Kansas City |
| All-League Second Team Fullback | Harvey Unga | Miami |
| All-League Second Team Tight End | John Phillips | New York (N) |
| All-League Second Team Wide Receiver | Everett Newton | Los Angeles |
| All-League Second Team Wide Receiver | Steve Smith Sr. | New York (A) |
| All-League Second Team Center | Josh Beekman | Detroit |
| All-League Second Team Offensive Guard | Seth Wand | Tennessee |
| All-League Second Team Offensive Guard | Branden Albert | Green Bay |
| All-League Second Team Offensive Tackle | Eric Winston | Denver |
| All-League Second Team Offensive Tackle | Levi Brown | New Orleans |
| All-League Second Team Punter | Brandon Fields | San Diego |
| All-League Second Team Kicker | Matthew Molinet | Dallas |
| All-League Second Team Defensive End | Darrell Shrophire | Cincinnati |
| All-League Second Team Defensive End | Jovan Haye | Kansas City |
| All-League Second Team Defensive Tackle | Osi Umenyiora | St. Louis |
| All-League Second Team Defensive Tackle | Phil Taylor | New York (N) |
| All-League Second Team Inside Linebacker | Nate Irving | New York (N) |
| All-League Second Team Outside Linebacker | Desmond Bishop | San Francisco |
| All-League Second Team Outside Linebacker | Paul Posluszny | Cleveland |
| All-League Second Team Cornerback | Chris Houston | San Francisco |
| All-League Second Team Cornerback | Mike Mitchell | Oakland |
| All-League Second Team Safety | Corey Webster | Chicago |
| All-League Second Team Safety | Zachery Bowman | Atlanta |
| League's Fastest Man | A.J. Green | Jacksonville |
| League's Strongest Man | Taylor Whitley | San Diego |