| San Francisco | Tack | Asst | Sack | RPlay | PPlay | | ILB Marquis Swift | 9 | 1 | 0.0 | 16 | 16 | | CB Dominique Keillor | 7 | 0 | 0.0 | 21 | 27 | | S Wally Dillon | 4 | 0 | 0.0 | 8 | 19 | | ILB Jerry Flynn | 3 | 3 | 0.0 | 7 | 16 | | S James Williams | 3 | 2 | 0.0 | 23 | 31 | | OLB Desmond Howry | 3 | 0 | 0.0 | 17 | 19 | | CB Ross Graham | 3 | 0 | 0.0 | 11 | 14 | | DE Anthony Snedden | 2 | 0 | 1.5 | 5 | 10 | | CB Maurice Kerr | 2 | 1 | 0.0 | 19 | 28 | | DT John Forbes | 2 | 0 | 0.0 | 17 | 19 | | DT Blake Turner | 2 | 0 | 0.0 | 11 | 23 | | ILB Donte Hanson | 1 | 1 | 0.0 | 4 | 3 | | DE Erick Covington | 1 | 0 | 0.0 | 16 | 13 | | DE Dustin Erickson | 0 | 1 | 0.5 | 7 | 18 | | S Alontae Taylor | 0 | 2 | 0.0 | 17 | 17 | | DT Pat Butler | 0 | 2 | 0.0 | 14 | 10 | | DE Lamont Foley | 0 | 2 | 0.0 | 14 | 10 | | S Devante Ivans | 0 | 1 | 0.0 | 13 | 20 |
| | Buffalo | Tack | Asst | Sack | RPlay | PPlay | | OLB David Bartholomew | 10 | 2 | 0.0 | 28 | 26 | | ILB Randy Bernard | 8 | 3 | 0.0 | 25 | 18 | | S Dadrion Taylor-Demerson | 5 | 3 | 0.0 | 36 | 22 | | DT Travis Burroughs | 4 | 3 | 0.0 | 37 | 22 | | DT Vincent Clements | 4 | 3 | 0.0 | 26 | 24 | | S Chase Yohn | 3 | 2 | 0.0 | 23 | 23 | | DT Branden Boone | 3 | 1 | 0.0 | 17 | 10 | | CB Arnold Moretti | 3 | 0 | 0.0 | 39 | 27 | | OLB Kenneth Nixon | 3 | 0 | 0.0 | 18 | 26 | | DT Sammy Whalen | 2 | 1 | 0.0 | 21 | 19 | | CB Louie Russell | 2 | 1 | 0.0 | 10 | 0 | | S Erick Brautlacht | 2 | 0 | 0.0 | 17 | 5 | | DE Roger Torres | 2 | 0 | 0.0 | 19 | 15 | | CB Rod Bryant | 1 | 3 | 0.0 | 32 | 24 | | ILB Mel Hawkins | 1 | 0 | 0.0 | 17 | 8 | | DE Darius Robinson | 1 | 0 | 0.0 | 22 | 13 | | OLB Marist Liufau | 0 | 2 | 0.0 | 15 | 5 | | ILB Miguel Fau | 0 | 1 | 0.0 | 12 | 1 | | CB Jim Enloe | 0 | 1 | 0.0 | 11 | 5 |
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